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Retatrutide titration: 1mg to 12mg The retatrutide titration protocol tested in Phase 3 trials follows a five-step escalation: Weeks 1-4: 1mg weekly Weeks 5-8: 2mg weekly Weeks 9-12: 4mg weekly Weeks 13-16: 8mg weekly Week 17 onward: 12mg weekly (maximum dose) The dose doubles at each step (with the exception of the 1mg to 2mg increase), which is a faster escalation rate than either semaglutide or tirzepatide

doi: 10.1056/NEJMoa2206038 83 US National Institutes of Health

Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles

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Summary: Retatrutide can cause a dose-dependent increase in resting heart rate, with Phase 2 trials reporting mean rises of approximately 5 to 7 beats per minute at higher doses, likely driven by its GLP-1 and glucagon receptor agonism